* From Nature: “Forget lung, breast or prostate cancer: why tumour naming needs to change: The conventional way of classifying metastatic cancers according to their organ of origin is denying people access to drugs that could help them.” Notice: “To improve treatments for people with metastatic cancer, the community urgently needs to shift from using organ-based classifications of cancer to using molecular-based ones. This will require radical changes in how medical oncology is structured, conducted and taught.” Plus, this is consistent with my low view of the FDA’s current drug-denial regime:
For about a decade, millions of people with tumours expressing high levels of PD-L1 were not able to access relevant drugs because trials had not yet been conducted for their type of cancer when they became unwell. Those with certain breast or gynaecological cancers expressing PD-L1 had to wait 7–10 years to access PD1 inhibitors.
And how many people died while waiting? Why aren’t those estimates considered by the FDA?
* From my wife, Bess: “In defense of boring. An exciting story.” The start of the second paragraph still makes me laugh: “‘You’re boring,’ declares Dr. Sacco, Jake’s oncologist.”
* “Natalism as Non-Conformism.”
* “Interview: Sarah C. Paine: A scholar of the 20th century explains the conflicts of the 21st.” Impressive and thorough.
* “Taylor Swift, Donald Trump and the Right’s Abnormality Problem.” I don’t find football interesting—George will allegedly described it, memorably, as: “Football combines two of the worst things in American life. It is violence punctuated by committee meetings”—and Taylor Swift’s music is fine (“Bad Blood” is catchy), though I’m not her target audience. Yet this gets at something vital, though maybe not dispositive, if one is to believe polls. Another version of the argument may be found in “Taylor Swift Democrats: Conservatives are losing the ‘don’t be weirdos’ contest.”
* Biden should run on a message of abundance. IMO abundance is good. I’d prefer a substance of abundance over a message of abundance, personally.
* The end of Vitalik’s childhood. “[W]atching all of these people go further than I did, younger than I did, made me clearly realize that if that was ever my role, it is no longer.”
* How’d China come to dominate electric cars? Without Tesla, China would likely totally rule the electric car market. Tesla is among the most important companies, ever.
* “How cancer hijacks the nervous system to grow and spread.” Of particular interest because my tumor exhibited “perineural invasion,” which appears to have been way worse than I knew or thought at the time.
* “Citation cartels help some mathematicians—and their universities—climb the rankings.” In case you’re still somehow thinking that all is well in academe.
* “FDA devastation during the pandemic.” The FDA kills, and hardly anyone seems to care.
* “GoFundMe Is a Health-Care Utility Now: Resorting to crowdfunding to pay medical bills has become so routine, in some cases health professionals recommend it.” A problem and challenge I feel acutely. I love the mealy-mouthed bureaucratic responses from the hospitals.
* Podcast with “Jerry Hendrix: The Age of U.S. Naval Dominance Is Over.” His book is To Provide and Maintain: Why Naval Primacy Is America’s First Best Strategy. One of these things that is a lot more important than much of what one sees. Hendrix says China is building a new surface warship every six weeks, and the U.S. is building just six a year. Relatedly: why we can’t build enough artillery shells, in detail.
* Ten technologies that won’t exist in five years—but most of them could, and should, exist.